Depression is a psychological condition that affects up to 350 million people worldwide. The symptoms can range from mild to severe enough to cause disability. Although pharmaceutical manufacturers have developed many antidepressants to treat this condition, many patients find that the side effects make their continued use impossible. A natural compound called S-adenosyl methionine, or SAM-e, has been found to be helpful in treating cases of mild to moderate depression without these severe side effects.
What Is SAM-e?
S-adenosyl methionine a compound that found naturally in the body. In Europe, and categorized as a prescription medication, it has been used for many years to treat a variety of medical conditions. Many scientific studies found that S-adenosyl methionine can be helpful in relieving the symptoms of depression, as well as other physical and behavioral conditions. In the United States, categorized as a supplement that can be helpful in treating depression in those who prescription antidepressants were not helpful or who find these medications cause severe side effects.
Use 0f SAM-e in Treatment of Depression
The usefulness of SAM-e for treating both physical and psychological illnesses is still under study. However, the results of many studies, both in Europe and the United States, indicate that it can be effective for:
- Osteoarthritis pain
- Fibromyalgia pain
- Cholestasis, a liver disorder that occurs during pregnancy
- AIDS-related nerve disorders
- Possible effectiveness for other conditions, such as ADHD and hepatitis
How SAM-e Works
Research indicates that SAM-e works via many different biochemical processes. It breaks down into many different compounds that aid in regulating pain perception, mood, and concentration. The transmethylation pathway boosts dopamine, serotonin and norepinephrine production, which helps with mood regulation. The carbon groups donated by SAM-E provide stability for catecholamine neurons. SAM-e also believed to improve the way nerve cell membranes take in phospholipids, which helps to transmit neural impulses.
Side Effects From SAM-e
SAM-e considered safe to use and usually without severe side effects. However, some individuals may experience stomach upset, diarrhea, headache, nervousness or insomnia. Individuals with bipolar may experience mania. SAM-e can also make Parkinson’s disease symptoms worse. You must discontinue SAM-e at least two weeks before having surgery.
For depression, the recommended dosage is 400 milligrams to 1600 milligrams per day, depending on the severity of symptoms. If insomnia or nervousness results, take SAM-e early in the morning instead of later in the day. Older people or those with bipolar disorder or schizophrenia should begin with a lower dosage and gradually increase it as the body adjusts.
SAM-e recognized as an effective alternative to traditional pharmaceuticals and offers another option for individuals who prefer a more natural compound without unpleasant side effects.
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